An excellent training opportunity for junior or senior post-doctoral fellows is available in a dynamic cancer research laboratory of Marja Nevalainen, MD, PhD, Professor, Dept. of Pharmacology, Physiology and Cancer Biology at the NCI-designated Sidney Kimmel Cancer Center at Thomas Jefferson University in Philadelphia.
The candidate will investigate Jak-Stat signaling in prostate cancer diagnostics, progression and therapy, and how Jak-Stat signaling promotes cancer progression to therapy resistant metastatic disease using human specimens as well as PDX and cell culture models. Dr. Nevalainenrsquo;s group provided the proof-of-concept that Stat5 is a therapeutic target protein for prostate cancer. Her lab demonstrated that Stat5 controls prostate cancer cell viability and castrate-resistant prostate tumor growth, and Jak2-Stat5a/b signaling induces epithelial- mesenchymal transition and stem cell-like properties in prostate cancer cells. Dr. Nevalainenrsquo;s lab further discovered that the Stat5 locus is amplified in castrate-resistant and metastatic prostate cancer, followed by an important translational finding that elevated active Stat5 in prostate cancer prior to intent-to-cure radical prostatectomy predicts development of castrate-resistant and metastatic spread of the disease in patients. The Nevalainen laboratory identified a family of novel small molecule Stat5 inhibitors with high efficacy in both prostate cancer and Bcr-Abl-driven leukemias. One area of current focus is on Jak2-Stat5 regulation of DNA repair in prostate cancer, the associated transcriptional programs and utilization of Jak2-Stat5 suppression as an adjuvant to radiation therapy of prostate cancer. Other major areas include investigation of the molecular mechanisms underlying Jak2-Stat5induction of lineage plasticity and regulation of androgen receptor (AR) gene transcription and the AR transcriptome in prostate cancer and translation of the concept to the clinical space.
The ideal post-doc candidate should be highly motivated and demonstrate a passion for science, innovative thinking and the ability to work independently and effectively with the other members in the team. Previous knowledge in cancer biology is required with a minimum of one peer-reviewed publication. In addition, knowledge of scientific methodologies, procedures, and basic experimental theories/applications and strong critical/analytic thinking and ability to communicate effectively are required. This postdoctoral training position includes a strong support from the mentor for career development toward an independent investigator status.
Desired Knowledge, Skills, and Abilities:
Applicants must have communications skills, knowledge of scientific approach and methodologies, and ability to design and coordinate scientific research projects. The candidate is required to perform cell culture experiments using various methodologies. The fellow may also be requested to handle laboratory animals to understand basic biochemistry. Techniques include tissue culture, transfection, western blot analysis, RNA isolation along with other state of the art molecular, biochemical, immunohistochemistry, genomics and imaging methods. Trainees will receive training in a broad range of research methodologies and in writing scientific publications and grants. Studies involve in vivo and in vitro models of prostate cancer. Successful candidates must be organized and be able to work independently. This postdoctoral training position includes a strong support from the mentor for career development toward an independent investigator status.
Selected recent papers relevant to the open position:
Maranto C*, Udhane VU*, Sabharwal L*, Pitzen S, McCluskey B, Devi S, Johnson S, Jacobsohn K, Banerjee A, Iczkowksi KA, Wang L, Dehm S, Nevalainen MT. Stat5 induces androgen receptor (AR) gene transcription in prostate cancer and offers a druggable pathway to target androgen receptor signaling. In Revision, Science Advances, 2023
Contact:
Marja Nevalainen, MD, PhD:
Administrative Assistant: Jessica Tustin: Jessica.Tustin@jefferson.edu
Application Process:
Applications must contain the following documents in English.
Jefferson includes Thomas Jefferson University and Jefferson Health, a dynamic university and health system with broad reach across the Delaware Valley. Jefferson is the second largest employer in Philadelphia and the largest health system in Philadelphia based on total licensed beds.
Through the merger of Thomas Jefferson University and Philadelphia University in 2017, our University includes ten colleges and four schools. We are an NCAA Division II university and an R2 national doctoral university offering undergraduate and graduate-level programs that provide students with a forward-thinking education in architecture, business, design, engineering, fashion and textiles, health, medicine and social science.
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